Equipoise is necessary for randomising patients to clinical trials. Sample 1. Sample 2. Sample 3. Equipoise literally means a state of balance or equilibrium ; in the research context it means that, amongst health care experts , uncertainty prevails about whether a particular treatment or intervention is better than another.
This principle forms the basis for conducting clinical research. In reality, most clinical trials are conducted to verify the superiority of a new treatment over placebo This reminds me of the story of my aunt, who was involved in a clinical trial for Rheumatoid Arthritis patients many years ago. Since there was no standard treatment for Rheumatoid Arthritis at that time, it seemed to be acceptable to have both placebo and treatment groups in the trial.
Later it turned out that the physicians were favoring the new treatment much more than the placebo for some unknown reasons. Then shall we give up? At least FDA does not believe so. As biostatisticians, our responsibilities in conducting and monitoring experiments for medical patent applications always include Phase 3 Clinical trials. And many of such RCTs were designed with placebo groups. Test your visual vocabulary with our question challenge!
A daily challenge for crossword fanatics. Love words? Need even more definitions? Merriam-Webster's Words of the Week - Jan. Ask the Editors 'Everyday' vs. What Is 'Semantic Bleaching'? How 'literally' can mean "figuratively". Related Posts.
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